International Journal of
Medical Sciences
International Journal of Medical Sciences is a general medical research journal covering areas of basic medical sciences and clinical research related to the studies of human diseases. Articles include original research papers, reviews and short research communications. The Journal aims at rapid publication of high quality medical research results while maintaining rigorous review process. Full texts of published articles appear in PubMed Central, the U.S. National Institutes of Health (NIH) digital archive of biomedical journal literature, and abstracts are indexed in PubMed.
Editor-in-Chief:
Dr. Dennis D. Taub, Laboratory of Immunology, National Institute on Aging, NIH.
ISSN: 1449-1907
Frequency: Articles added continuously
Web site: http://www.medsci.org
Cancer Survivors in the United States: A Review of the Literature and a Call to Action
Manuel Valdivieso, Ann M. Kujawa, Tisha Jones, Laurence H. Baker
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Medsci.orgBackground: The number of cancer survivors in the U.S. has increased from 3 million in 1971, when the National Cancer Act was enacted, to over 12 million today. Over 70% of children affected by cancer survive more than 10 years, and most are cured. Most cancer survivors are adults, with two-thirds of them 65 years of age or older and two-thirds
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Inhaled Nitric Oxide Therapy Fails to Improve Outcome in Experimental Severe Influenza
Ilyse Darwish, Chris Miller, Kevin C. Kain, W. Conrad Liles
In vitro, nitric oxide (NO) has been shown to have antimicrobial activity against a wide range of viruses, including influenza A virus. Therefore, we hypothesized that inhaled nitric oxide (iNO) would increase survival in vivo by reducing the viral load in C57Bl/6 mice infected with a lethal dose of influenza A/WSN/33 (H1N1; WSN/33) virus. NO was
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Rapid Detection of rpoB Mutations in Rifampin Resistant M. tuberculosis from Sputum Samples by Denaturing Gradient Gel Electrophoresis
Jun Li, Jiaojiao Xin, Liyuan Zhang, Longyan Jiang, Hongcui Cao, Lanjuan Li
Objective: To establish a rapid detection method for identifying rpoB mutations associated with rifampin (RIF) resistance in sputum specimens.Methods: We detected rpoB mutations directly in 90 sputum specimens collected from suspected tuberculosis patients using PCR-based denaturing gradient gel electrophoresis (DGGE) and compared these results
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What Questions do People Ask on a Human Papillomavirus Website? A Comparative Analysis of Public and Private Questions
Sung-Jong Lee, Hae-Jung Yun, Keun-Ho Lee, Chan-Joo Kim, Jong-Sup Park
Objective: In 2004, we launched the question and answer (Q&A) section on a human papillomavirus (HPV) website (www.hpvkorea.org) that provides ample and regularly updated information about HPV. The purpose of this study is to collect data pertaining to questions posed on this website about HPV and its related diseases and analyze the type of
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Oral and Maxillofacial Considerations in Gardner's Syndrome
Abdulkadir Burak Cankaya, Mehmet Ali Erdem, Sabri Cemil Isler, Muhsin Cifter, Vakur Olgac, Cetin Kasapoglu, Cuneyt Korhan Oral
Gardner's Syndrome is a variant of familial adenomatosis polyposis (FAP) with a triad consisting of polyps of the colon, multiple osteomas and surface tumors of soft and hard tissue. The intestinal polyps have a %100 risk of undergoing malignant transformation, therefore early identification of this disease is very important. There are several
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Effects of Two Fluoride Varnishes and One Fluoride/Chlorhexidine Varnish on Streptococcus mutans and Streptococcus sobrinus Biofilm Formation in Vitro
Arzu Pinar Erdem, Elif Sepet, Güven Kulekci, Sule Can Trosola, Yegane Guven
Aims: The aim of this study was to evaluate and to compare the effect of two fluoride varnishes and one fluoride/chlorhexidine varnish on Streptococcus mutans and Streptococcus sobrinus biofilm formation, in vitro.Study design: Standard acrylic discs were prepared and divided into groups based on the varnish applied to the disc surface: Fluor
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Potential Impact of the Financial Crisis on Outpatient Hospital Visits due to Otorhinolaryngologic Disorders in Crete, Greece
Alexander D. Karatzanis, Emmanouil K. Symvoulakis, Vasilios Nikolaou, George A. Velegrakis
The public health effect of financial crises has been emphasized in previous studies. In addition, a series of otorhinolaryngologic disorders and manifestations has been related to psychological factors in the literature. Such conditions include temporomandibular joint disorders, laryngopharyngeal reflux, chronic tinnitus, and vertigo. Focusing on
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Relationship between Antithyroid Antibody and Pregnancy Outcome following in Vitro Fertilization and Embryo Transfer
Yi-ping Zhong, Ying Ying, Hai-tao Wu, Can-quan Zhou, Yan-wen Xu, Qiong Wang, Jie Li, Xiao-ting Shen, Jin Li
Objective: To investigate the impact of antithyroid antibody on pregnancy outcome following the in vitro fertilization and embryo transfer (IVF-ET).Methods: A total of 90 patients (156 cycles) positive for antithyroid antibody (ATA+ group) and 676 infertile women (1062 cycles) negative for antithyroid antibody (ATA- group) undergoing IVF/ICSI from
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Relationship of Visual Cortex Function and Visual Acuity in Anisometropic Amblyopic Children
Chuanming Li, Lin Cheng, Qiongwu Yu, Bing Xie, Jian Wang
Purpose: To detect the functional deficit of the visual cortex in anisometropic amblyopia children using functional magnetic resonance imaging (fMRI) technique, and investigate the relationship between visual acuity and visual cortex function.Methods: Blood oxygenation level-dependent fMRI (BOLD-fMRI) was performed in ten monocular anisometropic
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P-wave Dispersion for Predicting Paroxysmal Atrial Fibrillation in Acute Ischemic Stroke
Umuttan Dogan, Ebru Apaydin Dogan, Mehmet Tekinalp, Osman Serhat Tokgoz, Alpay Aribas, Hakan Akilli, Kurtulus Ozdemir, Hasan Gok, Betigul Yuruten
Background: Detection of paroxysmal atrial fibrillation (PAF) in acute ischemic stroke patients poses diagnostic challenge. The aim of this study was to predict the presence of PAF by means of 12-lead ECG in patients with acute ischemic stroke. Our hypothesis was that P-wave dispersion (Pd) might be a useful marker in predicting PAF in patients
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High-risk Human Papillomavirus Infection in Low Risk Women: Incidence, Patient Characteristics, and Clinical Meaning for Cervical Cancer
Sung Jong Lee, Seung Geun Yeo, Dong Choon Park
Objective: To investigate the incidence of high-risk human papillomavirus (HPV) infection and its clinical meaning.Methods: Total 28,339 women attending our hospital for routine gynecologic care underwent Papanicolaou test (PAP test) and high-risk HPV tests. Biopsies were taken from some women and their results were compared.Results: The
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Electrocardiographic Findings in Patients with Polycythemia Vera
Mehmet Kayrak, Kadir Acar, Enes Elvin Gul, Turyan Abdulhalikov, Murat Bağlıcaklıoğlu, Osman Sonmez, Zeynettin Kaya, Hatem Arı
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Medsci.orgBackground: The 12-lead surface electrocardiogram (ECG) is a useful tool to predict both atrial and ventricular arrhythmias via P-wave and QT measurements and its derivatives. Polycythemia vera (PV) is a chronic myeloproliferative disorder associated with cardiovascular events. The aim of this study was to assess ECG findings of patients with
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Effects of Female Sex Hormones on Clusterin Expression and Paclitaxel Resistance in Endometrial Cancer Cell Lines
Yong Sung Won, Sung Jong Lee, Seung Geun Yeo, Dong Choon Park
Objective: We have analyzed the association between clusterin expression in endometrial cancer cells and their resistance to paclitaxel. We also analyzed whether the effects of female sex hormones on clusterin expression by these cell lines affect their resistance to paclitaxel. Methods: The expression of estrogen receptors α and β,
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Tender Papule Rising on the Digit: Pacinian Neuroma Should Be Considered in Differential Diagnosis
Hyun Hee Cho, Jong Soo Hong, Se Young Park, Hyun Sun Park, Soyun Cho, Jong Hee Lee
Pacinian corpuscles are sensory nerve-end organs located in the deep dermis and subcutaneous tissue of the palms or soles. Pacinian neuroma is an extremely rare feature, defined as hyperplasia or hypertrophy of Pacinian corpuscles. About half of Pacinian neuromas present with point tenderness. There have been a limited number of cases reported
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Early Biventricular Molecular Responses to an Acute Myocardial Infarction
Cenk Erdal, Gökhan Karakülah, Emel Fermancı, İmge Kunter, Erdem Silistreli, Tülay Canda, Esra Erdal, Hasan Hepaguslar
Background: Acute myocardial infarction (AMI) remains as one of the most common lethal diseases in the world and therefore it is necessary to understand its effect on molecular basis. Genome-wide microarray analysis provides us to predict potential biomarkers and signaling pathways for this purpose.Objectives: The aim of this study is to
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Clinicopathological Characteristics and Prognosis of Non-Small Cell Lung Cancer Patients Associated with a Family History of Lung Cancer
Shuji Haraguchi, Kiyoshi Koizumi, Iwao Mikami, Okamoto Junichi, Yoshihito Iijima, Takayuki Ibi, Kazuo Shimizu
Introduction: Clinicopathological characteristics and prognosis of non-small cell lung cancer (NSCLC) patients with a family history of lung cancer (FHLC) have not been well established.Methods: Clinical records of patients with NSCLC treated at our institute from 1982 to 2010 were reviewed with special reference to family history of lung cancer
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Delayed Intracerebral Hemorrhage Secondary to Ventriculoperitoneal Shunt: Two Case Reports and a Literature Review
Feng Zhou, Qichang Liu, Guangyu Ying, Xiangdong Zhu
Ventriculoperitoneal (VP) shunt has become a popular operation to achieve cerebrospinal fluid (CSF) diversion, but is associated with many complications. Postoperative delayed intracerebral hemorrhage is a kind of rare but severe event, which has not thus far been reported in retrospective case analyses. Here we present two cases of delayed
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A Randomized Clinical Trial Comparing the Effect of Rapidly Infused Crystalloids on Acid-Base Status in Dehydrated Patients in the Emergency Department
Hakan Hasman, Orhan Cinar, Ahmet Uzun, Erdem Cevik, Loni Jay, Bilgin Comert
Study objective: To compare the effect of normal saline (NS), lactated Ringer's, and Plasmalyte on the acid-base status of dehydrated patients in the emergency department (ED).Method: We conducted a prospective, double-blind, randomized trial of consecutive adult patients who presented to the emergency department with moderate-severe dehydration.
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The GHS-R Blocker D-[Lys3] GHRP-6 Serves as CCR5 Chemokine Receptor Antagonist
Kalpesh Patel, Vishwa Deep Dixit, Jun Ho Lee, Jie Wan Kim, Eric M. Schaffer, Dzung Nguyen, Dennis D. Taub
[D-Lys3]-Growth Hormone Releasing Peptide-6 (DLS) is widely utilized in vivo and in vitro as a selective ghrelin receptor (GHS-R) antagonist. This antagonist is one of the most common antagonists utilized in vivo to block GHS-R function and activity. Here, we found that DLS also has the ability to modestly block chemokine function and ligand
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Oral Infection by Staphylococcus Aureus in Patients Affected by White Sponge Nevus: A Description of Two Cases Occurred in the Same Family
Massimo Marrelli, Marco Tatullo, Gianna Dipalma, Francesco Inchingolo
Introduction. White Sponge Nevus (WSN) is a rare pathology with a pathogenesis on genetic basis, a benign course and a localization affecting the mucosal keratin.WSN is usually a symptomless pathology: when pain is present, some authors reported reduction of symptoms by taking penicillin or oral tetracycline rinses, suggesting that a bacterial
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The Simplified Edinburgh Postnatal Depression Scale (EPDS) for Antenatal Depression: Is It a Valid Measure for Pre-Screening?
Sea Kyung Choi, Jung Jin Kim, Yong Gyu Park, Hyun Sun Ko, In Yang Park, Jong Chul Shin
The identification of antenatal depression is critical but poorly conducted. The aim of this study was to construct a simplified depression survey scale and to verify its efficacy as a pre-screening for antenatal depression. A total of 494 pregnant women in the third trimester of gestation who had received antenatal care at Seoul St. Mary's
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Adverse Event Profiles of 5-Fluorouracil and Capecitabine: Data Mining of the Public Version of the FDA Adverse Event Reporting System, AERS, and Reproducibility of Clinical Observations
Kaori Kadoyama, Ikuya Miki, Takao Tamura, JB Brown, Toshiyuki Sakaeda, Yasushi Okuno
Objective: The safety profiles of oral fluoropyrimidines were compared with 5-fluorouracil (5-FU) using adverse event reports (AERs) submitted to the Adverse Event Reporting System, AERS, of the US Food and Drug Administration (FDA).Methods: After a revision of arbitrary drug names and the deletion of duplicated submissions, AERs involving 5-FU
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Efficacy of Lamivudine or Entecavir on Acute Exacerbation of Chronic Hepatitis B
Tatsuo Kanda, Masami Shinozaki, Hidehiro Kamezaki, Shuang Wu, Shingo Nakamoto, Makoto Arai, Keiichi Fujiwara, Nobuaki Goto, Fumio Imazeki, Osamu Yokosuka
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Medsci.orgBackground/Aims: Spontaneous acute exacerbation of chronic hepatitis B virus (HBV) infection occasionally occurs in its natural history, sometimes leading rapidly to fatal hepatic failure. We compared the effects of lamivudine (LAM) with those of entecavir (ETV) treatments in acute exacerbation of chronic hepatitis B with 500 IU/L or higher
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Cystic Lesions of the Jaws - A Clinicopathological Study of 322 Cases and Review of the Literature
Esther Manor, Leonid Kachko, Max B. Puterman, George Szabo, Lipa Bodner
Three hundred and twenty-two patients (192 male and 130 female) with cystic lesions of the jaw were successfully diagnosed and treated. One hundred and fifty-five (48%) were radicular cysts, 80 (25%) were dentigerous cysts, 23 (7%) were odontogenic keratocyst (=keratocystic odontogenic tumor), 19 (6%) were eruption cysts, 16 (5%) were traumatic
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Comparison of Laparoscopic and Laparotomic Surgery for the Treatment of Peritoneal Inclusion Cyst
Suk Woo Lee, Sung Jong Lee, Dong Gyu Jang, Joo Hee Yoon, Jang Heub Kim
Objectives: Peritoneal inclusion cyst (PIC) is defined as a fluid-filled mesothelial-lined cysts of the pelvis and it is most frequently encountered in women of reproductive age. The treatment options are observation, hormonal management, imaging-guided aspiration, image-guided sclerotherapy and surgical excision. The objective of this study is to
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Traumatic Hemorrhage within a Cerebellar Dermoid Cyst
Yongxin Luan, Haifeng Wang, Yanping Zhong, Xinchao Bian, Yinan Luo, Pengfei Ge
Intracranial dermoid cysts with hemorrhage are fairly rare. Herein, we reported a 28-year-old female patient with a cerebellar dermoid cyst, which was found accidently on neuro-imaging after head trauma. MR scanning revealed that the lesion was located within the cerebellar vermis and was measured 3.5cm×3.9cm×3.0cm, with hyper-intensity
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Improved Synthesis Strategy for Peptide Nucleic Acids (PNA) appropriate for Cell-specific Fluorescence Imaging
Rüdiger Pipkorn, Manfred Wiessler, Waldemar Waldeck, Ute Hennrich, Kiyoshi Nokihara, Marcel Beining, Klaus Braun
Progress in genomics and proteomics attended to the door for better understanding the recent rapid expanding complex research field of metabolomics. This trend in biomedical research increasingly focuses to the development of patient-specific therapeutic approaches with higher efficiency and sustainability. Simultaneously undesired adverse
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